- MINIFOR control unit equipped with a high precision thermal massflow meter (0 - 5000 ml/min)
- LAMBDA eliminated critical points to make sterility maintenance easy for long continuous runs
- Complete physical closure of the vessels obtained with silicone sterility membrane, permanent multipoint sealing, double seal conical PEEK connectors and septum
- Sterility is equivalent to magnetic coupling but is considerably less complex and much less expensive
- O-rings were replaced by large silicone stoppers with multipoint seals
- Sterilized by autoclaving, no need of SIP
- Reliable peristaltic pumps with sterile and short liquid line connection
- Comply with GMP / GLP and SOP
Unique sterility construction
Sterility is the most important quality (CCP) of fermentors and bioreactors in laboratories, which must be easy to obtain and maintain for long time. In continuous processes, the culture must be sterile for several weeks or the resulting loss of time and money would be higher than the acquisition cost of the bioreactor itself (e.g. contamination of CHO cells or other animal cell lines are way too expensive).
LAMBDA invested time and energy to find out the optimal solution which ensures perfect sterility maintenance for each run.
Complete physical closure (sealing) of the vessel from the outer environment is achieved with one large central elastic membrane and the new non-rotational agitation system. The sterility is thus equivalent to magnetic coupling, but is considerably less complex and much less expensive.
Head plates are eliminated and the vessels are constructed with several side necks / ports which are completely sealed with permanent stoppers with multiple seals. The problem with replacement of deformed O-rings before each runs are avoided with these multipoint sealing stoppers.
Reliable peristaltic pumps offer stable and reproducible flow rates for several weeks without the risk of tubing rupture. All the tubing connections to ports and storage bottles are made aseptic with the special LAMBDA double-seal tubing connectors.
Although LAMBDA MINIFOR only takes minimal laboratory bench surface, the connections are easily accessible: side necks for the probes and ports are positioned at an angle of 30°. The gained space allows easy sterility maintanance.
MINIFOR fermentor and bioreactor vessel ports with LAMBDA septum for aseptic inoculation (small volume, multi-track needle channel) and other ports for aseptic large volume (single-track needle channels) like acid, base, antifoam, media supplements, harvest, feed, or sampling.
The number of sterile connections / ports to each side neck of the culture vessels can be customized.
Easy to maintain aseptic conditions
Maintain aseptic conditions of batch, fed-batch or continuous fermentation and cell culture with the unique easy sterility concept of LAMBDA.
Safe & quick sterilization by autoclaving (standard SOP)
Best visibility into the vessel, optimal access to all parts and requires minimal connection distances
Compact MINIFOR fermentor can also fit in the glove box or sterile bench, not only in the clean room
Complete closure with multipoint sealing stoppers for ports & sterility membrane for stirrer
LAMBDA septum for inoculation
Reliable peristaltic pumps for feed, harvest, … with a sterile fluid pathway
Quick & easy cleaning
Quick setting up and cleaning of fermentor vessel – just like closing / opening bottle cap!
Short downtime and high productivity
Easy cleaning of external surfaces with disinfectant: fermentor console is coated with solvent resistant surface